fightn-CKD Study

The fightn-CKD Study is testing an investigational drug to see whether it could help people with high blood pressure (hypertension) and chronic kidney disease (CKD). A high dose and a low dose of the investigational drug will be compared with a placebo. A placebo looks exactly like the investigational drug but contains no active medication.

You may be able to take part in this study if you:

  • Are 18 years of age or over

  • Have hypertension and CKD

  • Are currently taking medication to lower your blood pressure

What is the fightn-CKD Study?

The fightn-CKD Study could last up to 8 months and is made up of 3 parts:

Part 1

Screening (up to 4 weeks)

If you are interested in taking part, you will be invited to Lucida Clinical to have tests and assessments. You will also receive the investigational drug or placebo for 2 weeks.

Part 2

Study treatment (26 weeks)

If the results show that you can take part, you will receive the investigational drug or placebo and visit Lucida Clinical for further tests.

Part 3

Follow-up

Around 2 weeks after your last dose of the study drug, you will return to Lucida Clinical for final health checks.

fightn-CKD Study Q & A

  • The investigational drug is designed to block the production of a hormone, aldosterone, which is linked to hypertension. Researchers believe that lowering aldosterone levels could help reduce blood pressure and improve kidney function.

  • During screening, all participants will receive the same study drug. During the study treatment period, you will have a 2 in 3 chance of receiving the investigational drug and a 1 in 3 chance of receiving placebo. A computer will randomly select which study drug you receive. You will not know whether you are receiving the investigational drug or placebo.

  • Throughout the study, you will continue to take your blood pressure-lowering medication as prescribed by your regular doctor. If applicable, you will also continue any blood sugar-lowering medication you may be taking.

  • You will be asked to attend the study center about 12 times to have tests. The purpose of these tests is to check on your health and to see how you are responding to the study drug.

    Tests include:

    • Physical examination.

    • Measurements of your blood pressure, pulse, breathing rate and body temperature.

    • ECG, which measures the rate and rhythm of your heart.

    • Collection of blood and urine samples.